C11orf35 antibody (AA 155-634)

Catalog No. ABIN7871011

The Rabbit Polyclonal anti-C11orf35 antibody (ABIN7871011) specifically detects C11orf35 in ELISA, FACS and WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for C11orf35 antibody (AA 155-634) (ABIN7871011)

Target: C11orf35 (Chromosome 11 Open Reading Frame 35 (C11orf35))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C11orf35 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Western Blotting (WB)

Product Details anti-C11orf35 Antibody

Binding Specificity: AA 155-634

Purpose: LMNTD2 Antibody / Lamin tail domain-containing protein 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human LMNTD2 recombinant protein (Position: E155-A634) was used as the immunogen for the LMNTD2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LMNTD2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LMNTD2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for C11orf35

Target: C11orf35 (Chromosome 11 Open Reading Frame 35 (C11orf35))

Alternative Name: LMNTD2

Background: The LMNTD2 antibody targets Lamina-associated polypeptide 2-like protein, encoded by the LMNTD2 gene. This protein belongs to a family of nuclear envelope-associated proteins that contribute to maintaining nuclear architecture and regulating gene expression. Lamina-associated polypeptide 2-like protein contains conserved coiled-coil and spectrin-repeat regions that enable interactions with nuclear envelope components and cytoskeletal elements. The LMNTD2 antibody supports detailed study of nuclear organization, mechanotransduction, and gene regulation processes mediated by the nuclear lamina.

Lamina-associated proteins link chromatin to the inner nuclear membrane and regulate nuclear stiffness, positioning, and transcriptional activity. Although the precise function of Lamina-associated polypeptide 2-like protein remains under characterization, studies suggest it participates in nuclear envelope remodeling during cell division and differentiation. The LMNTD2 antibody enables researchers to localize the protein in interphase nuclei and monitor its redistribution during mitosis, offering insights into how nuclear membrane components influence cell cycle progression.

LMNTD2 expression has been detected across multiple tissues, including brain, heart, and skeletal muscle, suggesting a structural role in maintaining nuclear integrity in mechanically active cells. The protein may interact with lamins (LMNA, LMNB1) and emerin to stabilize the nuclear lamina. Disruption of such interactions can alter chromatin organization and lead to nuclear shape abnormalities often associated with laminopathies and premature aging syndromes. The LMNTD2 antibody allows investigation of these interactions and potential implications in human disease.

Beyond structural maintenance, Lamina-associated polypeptide 2-like protein may influence transcriptional regulation by tethering specific genomic regions to the nuclear periphery. This positioning can repress or activate gene expression depending on chromatin context. The LMNTD2 antibody is valuable for examining spatial genome organization, nuclear compartmentalization, and mechanosensitive gene regulation, topics of growing interest in cell biology and epigenetics.

The LMNTD2 antibody is effective in immunofluorescence, western blotting, and immunohistochemistry, providing a clear nuclear envelope signal in cell-based assays. Its use helps identify structural changes in disease models, evaluate protein-protein interactions, and assess the impact of mechanical stress on nuclear organization. NSJ Bioreagents provides the LMNTD2 antibody as a reliable and validated reagent for studies of nuclear envelope biology. Through consistent detection and quantification, this antibody supports research on how Lamina-associated polypeptide 2-like protein contributes to nuclear integrity, gene expression, and cellular mechanotransduction.

UniProt: Q8IXW0