IFI44L antibody (AA 16-452)

Catalog No. ABIN7871081

This Rabbit Polyclonal antibody specifically detects IFI44L in WB, ELISA, IHC, IF, ICC and FACS. It exhibits reactivity toward Human, Mouse, Monkey and Rat.

Quick Overview for IFI44L antibody (AA 16-452) (ABIN7871081)

Target: IFI44L (Interferon-Induced Protein 44-Like (IFI44L))

Reactivity: Human, Mouse, Monkey, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFI44L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-IFI44L Antibody

Binding Specificity: AA 16-452

Purpose: IFI44L Antibody / Interferon-induced protein 44-like

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human IFI44L recombinant protein (Position: R16-I452) was used as the immunogen for the IFI44L antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the IFI44L antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the IFI44L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for IFI44L

Target: IFI44L (Interferon-Induced Protein 44-Like (IFI44L))

Alternative Name: IFI44L

Background: IFI44L antibody detects Interferon-induced protein 44-like, an interferon-stimulated gene product that mediates antiviral defense and immune regulation. IFI44L is strongly induced by type I interferons and viral infection and contributes to suppression of viral replication and modulation of innate immune signaling. The IFI44L antibody is widely used in immunology and virology research to study interferon responses and antiviral mechanisms.

IFI44L is encoded by the IFI44L gene on human chromosome 1p31.1. The protein is approximately 444 amino acids in length and localizes primarily in the cytoplasm, with some nuclear presence following interferon stimulation. Although its exact biochemical function remains under investigation, IFI44L is known to interact with cytoskeletal and RNA-binding proteins, influencing viral RNA recognition and replication.

The IFI44L antibody detects a 49 kilodalton protein by western blot and shows diffuse cytoplasmic staining under immunofluorescence microscopy. IFI44L expression is tightly correlated with type I interferon activity, serving as a biomarker for systemic lupus erythematosus and other interferonopathies. It enhances the antiviral state by restricting replication of RNA viruses such as influenza, hepatitis C, and coronaviruses through modulation of double-stranded RNA signaling and translation inhibition.

In addition to antiviral roles, IFI44L modulates immune cell differentiation and inflammation. Elevated IFI44L levels contribute to interferon signature profiles observed in autoimmune diseases, whereas reduced expression can impair viral clearance. Epigenetic regulation of the IFI44L promoter influences susceptibility to immune dysregulation and chronic infection.

Because IFI44L serves as a downstream effector of interferon signaling, it provides a useful marker for evaluating innate immune activation and viral suppression. NSJ Bioreagents provides a validated IFI44L antibody optimized for its applications, supporting research into antiviral defense, immune regulation, and interferon-stimulated gene expression.

UniProt: Q53G44