WDR37 antibody (AA 161-451)

Catalog No. ABIN7871109

The Rabbit Polyclonal anti-WDR37 antibody is suitable to detect WDR37 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB and FACS.

Quick Overview for WDR37 antibody (AA 161-451) (ABIN7871109)

Target: WDR37 (WD Repeat Domain 37 (WDR37))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR37 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-WDR37 Antibody

Binding Specificity: AA 161-451

Purpose: WDR37 Antibody / WD repeat-containing protein 37

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human WDR37 recombinant protein (Position: D161-Q451) was used as the immunogen for the WDR37 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the WDR37 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the WDR37 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for WDR37

Target: WDR37 (WD Repeat Domain 37 (WDR37))

Alternative Name: WDR37

Background: WDR37 antibody detects WD repeat-containing protein 37, a member of the WD40 domain protein family that serves as a scaffolding component in numerous multiprotein complexes. WD repeat proteins coordinate protein-protein interactions and are involved in processes such as vesicular trafficking, signal transduction, RNA processing, and cell cycle regulation. WDR37 is conserved across species and is characterized by multiple WD40 repeats forming a beta-propeller structure that mediates molecular recognition events. The WDR37 antibody is valuable for studies exploring signal transduction pathways, protein complex assembly, and developmental regulation.

WDR37 is encoded by the WDR37 gene located on human chromosome 10p15.1. The protein is ubiquitously expressed, with higher levels in brain, kidney, and reproductive tissues. Its precise molecular function remains under investigation, but emerging evidence suggests roles in intracellular signaling and vesicle trafficking. Mutations in WDR37 have been linked to a congenital neurodevelopmental disorder featuring craniofacial and ocular anomalies, underscoring its importance in human development. Studies in animal models indicate that Wdr37 contributes to ciliary and cytoskeletal organization, reflecting a potential connection to ciliopathies.

Using the WDR37 antibody, researchers can detect the native ~55 kDa protein via western blot and localize it through immunofluorescence microscopy. Expression analysis demonstrates cytoplasmic and perinuclear localization, consistent with a role in vesicular trafficking. The antibody is also useful in co-immunoprecipitation experiments for identifying interacting partners within signaling and transport complexes. Functional studies are beginning to connect WDR37 with cell cycle progression and protein degradation pathways, suggesting a role in maintaining proteostasis.

WD repeat proteins like WDR37 often act as adaptors within ubiquitin ligase complexes, G-protein signaling pathways, or RNA splicing assemblies. Understanding WDR37 biology could shed light on how these complexes maintain cellular organization and developmental homeostasis. NSJ Bioreagents provides a validated WDR37 antibody optimized for western blot and immunocytochemistry, supporting ongoing research into WD40 domain protein function, developmental biology, and molecular pathology.

UniProt: Q9Y2I8