Cathepsin K antibody (AA 163-274)

Catalog No. ABIN7871122

The Mouse Monoclonal anti-Cathepsin K antibody (Clone CTSK-2793) (ABIN7871122) specifically detects Cathepsin K in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Cathepsin K antibody (AA 163-274) (ABIN7871122)

Target: Cathepsin K (CTSK)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin K antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CTSK-2793

Product Details anti-Cathepsin K Antibody

Binding Specificity: AA 163-274

Purpose: Cathepsin K Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 163-274) was used as the immunogen for the Cathepsin K antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Cathepsin K antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Cathepsin K antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: Cathepsin K

Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades