PCDHA11 antibody (AA 163-324)

Catalog No. ABIN7871125

The Rabbit Polyclonal anti-PCDHA11 antibody (ABIN7871125) specifically detects PCDHA11 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PCDHA11 antibody (AA 163-324) (ABIN7871125)

Target: PCDHA11 (Protocadherin alpha 11 (PCDHA11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHA11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PCDHA11 Antibody

Binding Specificity: AA 163-324

Purpose: PCDHA11 Antibody / Protocadherin alpha 11

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human PCDHA11 recombinant protein (Position: E163-K324) was used as the immunogen for the PCDHA11 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PCDHA11 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PCDHA11 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PCDHA11

Target: PCDHA11 (Protocadherin alpha 11 (PCDHA11))

Alternative Name: PCDHA11

Background: PCDHA11 antibody detects Protocadherin alpha-11, encoded by the PCDHA11 gene on chromosome 5q31.3. PCDHA11 antibody is used in neuroscience and developmental biology, as PCDHA11 belongs to the protocadherin alpha gene cluster that encodes cadherin-like cell adhesion proteins. These molecules are highly expressed in the nervous system, where they contribute to neuronal diversity, connectivity, and synapse specification. The protocadherin cluster generates molecular diversity through combinatorial expression, enabling neurons to form specific connections.

Structurally, Protocadherin alpha-11 is a ~110 kDa type I transmembrane protein containing six extracellular cadherin repeats, a single-pass transmembrane domain, and a short cytoplasmic tail. The extracellular domains mediate calcium-dependent homophilic adhesion, while the cytoplasmic domain interacts with signaling molecules and cytoskeletal regulators. PCDHA11 is expressed predominantly in brain tissue, including cortex and hippocampus.

Functionally, PCDHA11 contributes to neuronal self-recognition and synapse formation. By expressing unique combinations of protocadherins, neurons establish cell-specific adhesion codes that guide connectivity. PCDHA11 also participates in dendritic arborization and neural circuit refinement. Researchers use PCDHA11 antibody to study neural adhesion, brain development, and synaptic patterning.

Clinically, protocadherins have been linked to neurodevelopmental disorders, epilepsy, and autism spectrum disorders. Altered expression or mutation of PCDHA11 may disrupt neuronal connectivity and contribute to cognitive dysfunction. Because protocadherins influence synaptic diversity, they are considered candidates for neurological disease biomarkers. NSJ Bioreagents offers PCDHA11 antibody for research in developmental neuroscience and neurogenetics.

Experimentally, PCDHA11 antibody is applied in western blotting to detect the ~110 kDa protein, in immunohistochemistry to visualize brain expression, and in immunofluorescence microscopy to examine synaptic localization. Co-immunoprecipitation with PCDHA11 antibody identifies interaction partners in cadherin and cytoskeletal networks.

UniProt: Q9Y5I1