IRF4 antibody (AA 163-419)

Catalog No. ABIN7871126

This Rabbit Polyclonal antibody specifically detects IRF4 in WB, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for IRF4 antibody (AA 163-419) (ABIN7871126)

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-IRF4 Antibody

Binding Specificity: AA 163-419

Purpose: Interferon regulatory factor 4 Antibody / IRF4 / MUM1

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids A163-Q419) was used as the immunogen for the Interferon regulatory factor 4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Interferon regulatory factor 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Interferon regulatory factor 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for IRF4

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Alternative Name: Interferon regulatory factor 4

Background: Interferon regulatory factor 4 (IRF4), also known as Multiple myeloma oncogene 1 (MUM1), is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.

UniProt: Q15306

Pathways: Chromatin Binding