PRDM6 antibody (AA 165-452)

Catalog No. ABIN7871147

This Rabbit Polyclonal antibody specifically detects PRDM6 in WB, ELISA, FACS, ICC and IF. It exhibits reactivity toward Human.

Quick Overview for PRDM6 antibody (AA 165-452) (ABIN7871147)

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-PRDM6 Antibody

Binding Specificity: AA 165-452

Purpose: PRDM6 Antibody / PR domain zinc finger protein 6

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human PRDM6 recombinant protein (Position: R165-R452) was used as the immunogen for the PRDM6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PRDM6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PRDM6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PRDM6

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Alternative Name: PRDM6

Background: The PRDM6 antibody targets PR domain zinc finger protein 6, a transcriptional repressor encoded by the PRDM6 gene. This protein is a member of the PRDM family, which combines a PR (PRDI-BF1 and RIZ1 homology) domain with multiple C2H2-type zinc fingers to regulate chromatin structure and gene expression. PR domain zinc finger protein 6 acts as an epigenetic modulator that influences vascular smooth muscle cell (VSMC) differentiation, proliferation, and contractility. The PRDM6 antibody allows precise detection of this transcriptional regulator, supporting studies into vascular development, remodeling, and disease.

PR domain zinc finger protein 6 functions as a transcriptional repressor by recruiting histone methyltransferases and corepressor complexes, leading to trimethylation of histone H3 on lysine 9 (H3K9me3) and gene silencing. It is preferentially expressed in smooth musclei 1/2derived lineages where it regulates genes controlling contractile protein synthesis and cell fate. The PRDM6 antibody provides a reliable means to monitor expression changes during phenotypic switching of VSMCs between contractile and proliferative states, a process central to vascular injury response and atherosclerosis.

Loss-of-function mutations in PRDM6 have been associated with patent ductus arteriosus (PDA) and other congenital heart defects. These variants impair transcriptional repression of target genes involved in vascular maturation. The PRDM6 antibody facilitates investigation into such pathogenic mechanisms by allowing detection of wild-type and mutant protein forms. In developmental studies, PR domain zinc finger protein 6 has been shown to coordinate the balance between smooth muscle proliferation and differentiation during embryogenesis, acting downstream of BMP and TGF-beta signaling pathways.

Beyond cardiovascular biology, PR domain zinc finger protein 6 has been implicated in oncogenesis through its role in epigenetic gene silencing. Aberrant PRDM6 expression or methylation patterns have been observed in multiple cancer types, suggesting that dysregulation of this transcriptional repressor contributes to uncontrolled cell growth. The PRDM6 antibody enables detailed exploration of its epigenetic regulatory activity in cancer and stem cell systems, providing insight into how histone modification and chromatin structure impact disease progression.

The PRDM6 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, showing predominant nuclear localization consistent with its transcriptional role. NSJ Bioreagents provides this antibody with validated specificity and consistency for use in molecular biology, vascular research, and epigenetic studies. By facilitating detailed analysis of PR domain zinc finger protein 6 expression and function, the PRDM6 antibody supports ongoing research into vascular development, gene regulation, and the epigenetic mechanisms that govern smooth muscle cell behavior.

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation