RBM22 antibody (AA 17-296)

Catalog No. ABIN7871219

This Rabbit Polyclonal antibody specifically detects RBM22 in WB. It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for RBM22 antibody (AA 17-296) (ABIN7871219)

Target: RBM22 (RNA Binding Motif Protein 22 (RBM22))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM22 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RBM22 Antibody

Binding Specificity: AA 17-296

Purpose: Zebrafish Rbm22 Antibody / RNA-binding protein 22

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Rbm22 recombinant protein (amino acids D17-R296) was used as the immunogen for the Zebrafish Rbm22 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Rbm22 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Rbm22 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RBM22

Target: RBM22 (RNA Binding Motif Protein 22 (RBM22))

Alternative Name: Rbm22

Background: Zebrafish Rbm22, also known as RNA binding motif protein 22, is a nuclear protein that plays an essential role in pre messenger RNA splicing. It is a component of the spliceosome complex and is critical for the correct processing and maturation of RNA transcripts. Rbm22 contains an RNA recognition motif that enables it to bind RNA and participate in the assembly of spliceosomal complexes during the splicing cycle.

Zebrafish Rbm22 is an ortholog of the human RBM22 protein and exhibits a high degree of sequence and functional conservation. In both zebrafish and humans, Rbm22 is involved in regulating alternative splicing events that contribute to the diversity of the transcriptome and the regulation of gene expression. Its function is particularly important during early development when precise control of splicing is required for cell differentiation and tissue formation.

There is currently limited evidence for multiple isoforms of zebrafish Rbm22, although alternative splicing is a common feature of RNA binding proteins, and further studies may reveal additional isoforms in the future. The zebrafish model provides an excellent system to study the conserved roles of Rbm22 in RNA metabolism and developmental processes.

Antibodies targeting zebrafish Rbm22 protein are valuable for research in RNA biology, splicing regulation, and gene expression studies. Given its orthology to human RBM22, studies using zebrafish Rbm22 can provide insights into conserved mechanisms of splicing regulation and its potential links to human disease.

UniProt: Q6NZZ9

Pathways: Protein targeting to Nucleus