Recombinant Dystrophin antibody (AA 1700-2300)

Catalog No. ABIN7871255

This Rabbit Monoclonal antibody specifically detects Dystrophin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant Dystrophin antibody (AA 1700-2300) (ABIN7871255)

Target: Dystrophin (DMD)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Dystrophin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: DMD-8773R

Product Details anti-Dystrophin Antibody

Binding Specificity: AA 1700-2300

Purpose: Dystrophin Antibody / DMD (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1700-2300) from the human protein was used as the immunogen for the Dystrophin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Dystrophin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Dystrophin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Dystrophin

Target: Dystrophin (DMD)

Alternative Name: Dystrophin

Background: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002 % of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development