DCK antibody (AA 171-200)

Catalog No. ABIN7871260

The Rabbit Polyclonal anti-DCK antibody (ABIN7871260) specifically detects DCK in WB, IF and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for DCK antibody (AA 171-200) (ABIN7871260)

Target: DCK (Deoxycytidine Kinase (DCK))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCK antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DCK Antibody

Binding Specificity: AA 171-200

Purpose: Deoxycytidine kinase Antibody / DCK

Purification: Purified

Immunogen: A portion of amino acids 171-200 from the human protein was used as the immunogen for the Deoxycytidine kinase antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Deoxycytidine kinase antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Deoxycytidine kinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for DCK

Target: DCK (Deoxycytidine Kinase (DCK))

Alternative Name: Deoxycytidine kinase

Background: Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.

UniProt: P27707