MUC4 antibody (AA 1730-1864)

Catalog No. ABIN7871278

The Mouse Monoclonal anti-MUC4 antibody (Clone MUC4-3105) (ABIN7871278) specifically detects MUC4 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for MUC4 antibody (AA 1730-1864) (ABIN7871278)

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUC4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: MUC4-3105

Product Details anti-MUC4 Antibody

Binding Specificity: AA 1730-1864

Purpose: MUC4 Antibody / Mucin-4 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Amino acids 1730-1864 from the human protein were used as the immunogen for this MUC4 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MUC4 antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the MUC4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Alternative Name: MUC4

Background: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity