LSP1 antibody (AA 174-278)

Catalog No. ABIN7871288

This Mouse Monoclonal antibody specifically detects LSP1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for LSP1 antibody (AA 174-278) (ABIN7871288)

Target: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LSP1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: LSP1-3025

Product Details anti-LSP1 Antibody

Binding Specificity: AA 174-278

Purpose: LSP1 Antibody / Lymphocyte Specific Protein 1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 174-278) was used as the immunogen for this LSP1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the LSP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the LSP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for LSP1

Target: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Alternative Name: LSP1

Background: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

UniProt: P33241