Reelin antibody (AA 1796-2115)

Catalog No. ABIN7871363

This Mouse Monoclonal antibody specifically detects Reelin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Reelin antibody (AA 1796-2115) (ABIN7871363)

Target: Reelin (RELN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Reelin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RELN-4498

Product Details anti-Reelin Antibody

Binding Specificity: AA 1796-2115

Purpose: Reelin Antibody / RELN

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1796-2115 was used as the immunogen for the Reelin antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Reelin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Reelin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Reelin

Target: Reelin (RELN)

Alternative Name: Reelin

Background: Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.

UniProt: P78509

Pathways: Synaptic Membrane