H2AFY antibody (AA 180-301)

Catalog No. ABIN7871442

The Rabbit Polyclonal anti-H2AFY antibody is suitable to detect H2AFY in samples from Human, Rat and Mouse. It has been validated for WB, IF, ELISA and IHC (p).

Quick Overview for H2AFY antibody (AA 180-301) (ABIN7871442)

Target: H2AFY (H2A Histone Family, Member Y (H2AFY))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H2AFY antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-H2AFY Antibody

Binding Specificity: AA 180-301

Purpose: MACROH2A1 Antibody / Core histone macro-H2A.1 / H2AFY

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids A180-K301) was used as the immunogen for the MACROH2A1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MACROH2A1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MACROH2A1 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for H2AFY

Target: H2AFY (H2A Histone Family, Member Y (H2AFY))

Alternative Name: MACROH2A1

Background: Core histone macro-H2A.1 is a protein that in humans is encoded by the MACROH2A1 gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: O75367