ALOX12 antibody (AA 186-628)

Catalog No. ABIN7871510

This Rabbit Polyclonal antibody specifically detects ALOX12 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ALOX12 antibody (AA 186-628) (ABIN7871510)

Target: ALOX12 (Arachidonate 12-Lipoxygenase (ALOX12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALOX12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ALOX12 Antibody

Binding Specificity: AA 186-628

Purpose: ALOX12 Antibody / 12S-lipoxygenase

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids A186-R628) was used as the immunogen for the ALOX12 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ALOX12 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ALOX12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ALOX12

Target: ALOX12 (Arachidonate 12-Lipoxygenase (ALOX12))

Alternative Name: ALOX12

Background: ALOX12, Arachidonate 12-lipoxygenase, is an enzyme that in humans is encoded by the ALOX12 gene. By fluorescence in situ hybridization, the ALOX12 gene is located in band 17p13.1. The gene consists of 14 exons with 13 introns and spans approximately 15 kb of DNA Arachidonate 12-lipoxygenase introduces a molecular oxygen into the C-12 position of arachidonic acid to produce 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid. The major pathway of arachidonic acid metabolism in human platelets proceeds via a 12-lipoxygenase enzyme. Expression of the LOG12 gene was detected in human erythroleukemia cells, platelets, and human umbilical vein endothelial cells by reverse transcription-PCR analysis.

UniProt: P18054

Pathways: Positive Regulation of Endopeptidase Activity