SMCR7L antibody (AA 189-463)

Catalog No. ABIN7871538

The Rabbit Polyclonal anti-SMCR7L antibody is suitable to detect SMCR7L in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IF, IP, FACS and IHC (p).

Quick Overview for SMCR7L antibody (AA 189-463) (ABIN7871538)

Target: SMCR7L (Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like (SMCR7L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMCR7L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SMCR7L Antibody

Binding Specificity: AA 189-463

Purpose: MIEF1 Antibody / Mitochondrial dynamics protein MID51

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids S189-T463) was used as the immunogen for the MIEF1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MIEF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MIEF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SMCR7L

Target: SMCR7L (Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like (SMCR7L))

Alternative Name: MIEF1

Background: MIEF1 antibody targets mitochondrial dynamics protein MID51, encoded by the MIEF1 gene. Mitochondrial dynamics protein MID51 is a mitochondrial outer membrane protein that plays a central role in regulating mitochondrial morphology by coordinating fission events. MID51 functions as an adaptor protein that recruits and modulates the activity of the dynamin-related GTPase DRP1, a core mediator of mitochondrial division. Through this interaction, MID51 contributes to the balance between mitochondrial fission and fusion that is essential for cellular homeostasis.

Functionally, mitochondrial dynamics protein MID51 regulates mitochondrial network organization in response to metabolic cues and cellular stress. By influencing DRP1 assembly and localization at mitochondrial constriction sites, MID51 impacts processes such as mitochondrial distribution, bioenergetic efficiency, and organelle quality control. A MIEF1 antibody supports studies focused on mitochondrial dynamics, organelle remodeling, and signaling pathways that link mitochondrial structure to cellular function.

MIEF1 expression has been reported in multiple cell types, reflecting the universal requirement for regulated mitochondrial dynamics. Subcellular localization is predominantly mitochondrial, consistent with its role at the outer mitochondrial membrane, although distribution can appear punctate or network-associated depending on mitochondrial state and cellular conditions. Alterations in MID51 levels or activity can shift mitochondrial morphology toward fragmented or elongated states, influencing downstream cellular responses.

From a disease relevance perspective, dysregulated mitochondrial dynamics involving MID51 have been investigated in neurodegenerative disease, cancer, and metabolic disorders, where imbalanced fission and fusion can contribute to altered energy metabolism and cell survival. At the molecular level, MID51 contains regulatory regions that mediate DRP1 binding and mitochondrial membrane association rather than intrinsic enzymatic activity. MIEF1 antibody reagents support research applications examining mitochondrial structure, stress responses, and organelle signaling pathways, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9NQG6