LYZ antibody (AA 19-151)

Catalog No. ABIN7871561

This Rabbit Polyclonal antibody specifically detects LYZ in WB and IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for LYZ antibody (AA 19-151) (ABIN7871561)

Target: LYZ (Lysozyme (LYZ))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LYZ antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LYZ Antibody

Binding Specificity: AA 19-151

Purpose: Zebrafish Lysozyme Antibody / Lyz

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Lysozyme recombinant protein (amino acids K19-A151) was used as the immunogen for the Zebrafish Lysozyme antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Lysozyme antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Lysozyme antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LYZ

Target: LYZ (Lysozyme (LYZ))

Alternative Name: Lysozyme

Background: Lysozyme is an antimicrobial enzyme that plays a key role in the innate immune system by breaking down bacterial cell walls. In zebrafish, lysozyme is expressed in immune cells such as neutrophils and macrophages and contributes to the early defense against bacterial infections.

Lysozyme functions by cleaving the glycosidic bonds in peptidoglycan, a major structural component of bacterial cell walls, particularly in gram positive bacteria. This activity leads to bacterial lysis and supports the clearance of pathogens from the host. In zebrafish, lysozyme genes are expressed during embryogenesis and are upregulated in response to infection or immune stimulation, making them important markers of immune activation.

Zebrafish lysozyme is highly conserved with its mammalian counterparts and is commonly used in research focused on host pathogen interactions, inflammation, and immune system development. It is also a valuable tool for studying the effects of genetic mutations, environmental exposures, or pharmaceuticals on immune responses in vivo.

Because of the transparency of zebrafish embryos and the availability of immune cell specific transgenic lines, lysozyme expression can be visualized and quantified in real time during infection and inflammation models. This makes zebrafish lysozyme a widely used marker in developmental immunology and disease research.

UniProt: Q90YS5