SUV420H2/KMT5C antibody (AA 195-220)

Catalog No. ABIN7871703

The Rabbit Polyclonal anti-SUV420H2/KMT5C antibody is suitable to detect SUV420H2/KMT5C in samples from Mouse and Human. It has been validated for WB and FACS.

Quick Overview for SUV420H2/KMT5C antibody (AA 195-220) (ABIN7871703)

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV420H2/KMT5C antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-SUV420H2/KMT5C Antibody

Binding Specificity: AA 195-220

Purpose: KMT5C Antibody / SUV420H2

Immunogen: A portion of amino acids 195-220 from the human protein was used as the immunogen for the KMT5C antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the KMT5C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the KMT5C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SUV420H2/KMT5C

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Alternative Name: KMT5C

Background: KMT5C, also called Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 and Suv4-20h2, belongs to a family of proteins called lysine methyltransferases, which are enzymes that play a key role in the modification of histone proteins. Histones are proteins that help package and organize DNA in the nucleus of a cell, and modifications to these proteins can have profound effects on gene expression. Studies have shown that KMT5C specifically targets histone H4 lysine 20 (H4K20) for methylation, which has been linked to the regulation of gene transcription and DNA replication. Dysregulation of this process has been implicated in various diseases, including cancer and developmental disorders. In cancer, aberrant expression of KMT5C has been observed in several tumor types, and its overexpression has been associated with poor prognosis. Mutations in the KMT5C gene have been linked to developmental disorders, such as intellectual disability and autism spectrum disorders. These findings highlight the importance of KMT5C in brain development and function, and provide new insights into the underlying mechanisms of these conditions.

UniProt: Q86Y97