PARK7/DJ1 antibody (AA 2-189)

Catalog No. ABIN7871779

The Mouse Monoclonal anti-PARK7/DJ1 antibody (Clone 4B10) (ABIN7871779) specifically detects PARK7/DJ1 in WB, IF, IHC (p) and FACS. The antibody is reactive with Human samples.

Quick Overview for PARK7/DJ1 antibody (AA 2-189) (ABIN7871779)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PARK7/DJ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 4B10

Product Details anti-PARK7/DJ1 Antibody

Binding Specificity: AA 2-189

Purpose: Parkinson disease protein 7 Antibody / PARK7

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids A2-D189) was used as the immunogen for the Parkinson disease protein 7 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Parkinson disease protein 7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Parkinson disease protein 7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: Parkinson disease protein 7

Background: Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene. PARK7 belongs to the peptidase C56 family of proteins. PARK7 is mapped to chromosome 1p36. It acts as a positive regulator of androgen receptor-dependent transcription. It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis. This gene may also function as a redox-sensitive chaperone, as a sensor foroxidative stress, and it apparently protects neurons against oxidative stress and cell death. It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport