SELT antibody (AA 20-195)

Catalog No. ABIN7871841

The Rabbit Polyclonal anti-SELT antibody is suitable to detect SELT in samples from Human, Mouse and Rat. It has been validated for ELISA, FACS, WB, IF and IHC (p).

Quick Overview for SELT antibody (AA 20-195) (ABIN7871841)

Target: SELT (Selenoprotein T (SELT))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SELT antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SELT Antibody

Binding Specificity: AA 20-195

Purpose: SELT Antibody / SELENOT

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids S20-S195) was used as the immunogen for the SELT antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SELT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SELT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SELT

Target: SELT (Selenoprotein T (SELT))

Alternative Name: SELT

Background: This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Thioredoxin reductase-like selenoprotein T is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5.

UniProt: P62341

Pathways: Cell RedoxHomeostasis