CXCR4 antibody (AA 20-352)

Catalog No. ABIN7871865

The Rabbit Polyclonal anti-CXCR4 antibody is suitable to detect CXCR4 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for CXCR4 antibody (AA 20-352) (ABIN7871865)

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-CXCR4 Antibody

Binding Specificity: AA 20-352

Purpose: CXCR4 Antibody

Purification: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids D20-S352) was used as the immunogen for the CXCR4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CXCR4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CXCR4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CXCR4

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Alternative Name: CXCR4

Background: CXCR4 (Chemokine, CXC Motif, Receptor 4), also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. It is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. CXCR4 is also a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1. It functions as a co-receptor for T-cell-line tropic human immunodeficiency virus HIV-1. It was concluded that PBSF/SDF-1 and CXCR4 define a new signaling system for organ vascularization.

UniProt: P61073

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events