IDO2 antibody (AA 200-350)

Catalog No. ABIN7871971

The Mouse Monoclonal anti-IDO2 antibody (Clone IDO2-2639) (ABIN7871971) specifically detects IDO2 in ELISA and IHC (p). The antibody is reactive with Human samples.

Quick Overview for IDO2 antibody (AA 200-350) (ABIN7871971)

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IDO2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IDO2-2639

Product Details anti-IDO2 Antibody

Binding Specificity: AA 200-350

Purpose: INDOL1 Antibody / IDO2

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 200-350 was used as the immunogen for the INDOL1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the INDOL1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the INDOL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IDO2

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Alternative Name: INDOL1

Background: IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.

UniProt: Q6ZQW0