AMBP antibody (AA 200-353)

Catalog No. ABIN7871976

The Mouse Monoclonal anti-AMBP antibody is suitable to detect AMBP in samples from Human. It has been validated for IHC (p).

Quick Overview for AMBP antibody (AA 200-353) (ABIN7871976)

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AMBP antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: AMBP-4533

Product Details anti-AMBP Antibody

Binding Specificity: AA 200-353

Purpose: AMBP Antibody / Bikunin / Alpha 1 Microglobulin (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 200-353) from the human protein was used as the immunogen for the AMBP antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the AMBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the AMBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for AMBP

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Alternative Name: AMBP

Background: The AMBP (Alpha-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated Alpha-1-Microglobulin and Bikunin. Alpha-1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, Alpha-1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter-Alpha-trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike Alpha-1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis.

UniProt: P02760