TGF-beta antibody (AA 200-390)

Catalog No. ABIN7871990

This Mouse Monoclonal antibody specifically detects TGF-beta in IHC (p). It exhibits reactivity toward Human.

Quick Overview for TGF-beta antibody (AA 200-390) (ABIN7871990)

Target: TGF-beta (TGFb)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGF-beta antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TGFB-7240

Product Details anti-TGF-beta Antibody

Binding Specificity: AA 200-390

Purpose: TGF beta Antibody / TGFB (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 200-390) from the human TGFB1 was used as the immunogen for the TGF beta antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TGF beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the TGF beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TGF-beta

Target: TGF-beta (TGFb)

Alternative Name: TGF beta

Background: This mAb recognizes TGF beta 1, 2 and 3. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80 % identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGF beta s inhibits the growth of epithelial cells and stimulate the growth of mesenchymal cells.

UniProt: P01137

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus