SMPD1 antibody (AA 204-558)

Catalog No. ABIN7872093

The Rabbit Polyclonal anti-SMPD1 antibody is suitable to detect SMPD1 in samples from Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for SMPD1 antibody (AA 204-558) (ABIN7872093)

Target: SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMPD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SMPD1 Antibody

Binding Specificity: AA 204-558

Purpose: aSMase Antibody / Smpd1 / Acid sphingomyelinase

Purification: Antigen affinity purified

Immunogen: Recombinant mouse protein (amino acids D204-M558) was used as the immunogen for the aSMase antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the aSMase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the aSMase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SMPD1

Target: SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))

Alternative Name: aSMase

Background: Sphingomyelin phosphodiesterase 1 (SMPD1), also known as acid sphingomyelinase (ASM or aSMase), is an enzyme that in humans is encoded by the SMPD1 gene. Enables acid sphingomyelin phosphodiesterase activity and zinc ion binding activity. Involved in ceramide biosynthetic process, positive regulation of apoptotic process, and response to ionizing radiation. Acts upstream of or within ceramide metabolic process, cholesterol metabolic process, and sphingomyelin catabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system, integumental system, nervous system, sensory organ, and skeleton. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease, Niemann-Pick disease type A, and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1).

UniProt: Q04519