C6orf150 antibody (AA 208-522)

Catalog No. ABIN7872110

This Rabbit Polyclonal antibody specifically detects C6orf150 in WB, ELISA, FACS and IF. It exhibits reactivity toward Human.

Quick Overview for C6orf150 antibody (AA 208-522) (ABIN7872110)

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C6orf150 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-C6orf150 Antibody

Binding Specificity: AA 208-522

Purpose: cGAS Antibody / cGAMP Synthase

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids L208-F522) was used as the immunogen for the cGAS antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the cGAS antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the cGAS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Alternative Name: cGAS

Background: CGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.

UniProt: Q8N884

Pathways: Activation of Innate immune Response