Recombinant Decorin antibody (AA 212-336)

Catalog No. ABIN7872210

The Rabbit Monoclonal anti-Decorin antibody is suitable to detect Decorin in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant Decorin antibody (AA 212-336) (ABIN7872210)

Target: Decorin (DCN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Decorin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DCN-8760R

Product Details anti-Decorin Antibody

Binding Specificity: AA 212-336

Purpose: Decorin Antibody / DCN

Purification: Protein A/G affinity

Immunogen: A recombinant human Decorin protein fragment (within amino acids 212-336) was used as the immunogen for the Decorin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Decorin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Decorin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Decorin

Target: Decorin (DCN)

Alternative Name: Decorin

Background: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFbeta and is a direct or indirect negative modulator of TGFbeta synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-gamma and TNFAlpha may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process