FCN3 antibody (AA 214-243)

Catalog No. ABIN7872226

The Rabbit Polyclonal anti-FCN3 antibody (ABIN7872226) specifically detects FCN3 in WB, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for FCN3 antibody (AA 214-243) (ABIN7872226)

Target: FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FCN3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FCN3 Antibody

Binding Specificity: AA 214-243

Purpose: Ficolin 3 Antibody / FCN3

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 214-243 from the human protein was used as the immunogen for the Ficolin 3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Ficolin 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Ficolin 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FCN3

Target: FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3))

Alternative Name: Ficolin 3

Background: Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.

UniProt: O75636

Pathways: Complement System