YWHAB antibody (AA 217-246)

Catalog No. ABIN7872246

The Rabbit Polyclonal anti-YWHAB antibody is suitable to detect YWHAB in samples from Human. It has been validated for WB, IF and IHC (p).

Quick Overview for YWHAB antibody (AA 217-246) (ABIN7872246)

Target: YWHAB (14-3-3 alpha + beta (YWHAB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YWHAB antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-YWHAB Antibody

Binding Specificity: AA 217-246

Purpose: YWHAB Antibody / 14-3-3 beta/alpha

Purification: Purified

Immunogen: A portion of amino acids 217-246 from the human protein was used as the immunogen for the YWHAB antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the YWHAB antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the YWHAB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for YWHAB

Target: YWHAB (14-3-3 alpha + beta (YWHAB))

Alternative Name: YWHAB

Background: YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

UniProt: P31946

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, Maintenance of Protein Location