PCDHA12 antibody (AA 219-365)

Catalog No. ABIN7872260

This Rabbit Polyclonal antibody specifically detects PCDHA12 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for PCDHA12 antibody (AA 219-365) (ABIN7872260)

Target: PCDHA12 (Protocadherin alpha 12 (PCDHA12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHA12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PCDHA12 Antibody

Binding Specificity: AA 219-365

Purpose: Protocadherin alpha 12 Antibody / PCDHA12

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids K219-V365) was used as the immunogen for the Protocadherin alpha 12 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Protocadherin alpha 12 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Protocadherin alpha 12 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PCDHA12

Target: PCDHA12 (Protocadherin alpha 12 (PCDHA12))

Alternative Name: Protocadherin alpha 12

Background: Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene. This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

UniProt: Q9UN75