CTSC antibody (AA 22-463)

Catalog No. ABIN7872325

The Rabbit Polyclonal anti-CTSC antibody (ABIN7872325) specifically detects CTSC in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for CTSC antibody (AA 22-463) (ABIN7872325)

Target: CTSC (Cathepsin C (CTSC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTSC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-CTSC Antibody

Binding Specificity: AA 22-463

Purpose: CTSC Antibody / Cathepsin C

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids V22-L463) was used as the immunogen for the CTSC antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CTSC antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CTSC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CTSC

Target: CTSC (Cathepsin C (CTSC))

Alternative Name: CTSC

Background: Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I) is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup of the cysteine cathepsins. In humans, it is encoded by the CTSC gene. This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

UniProt: P53634