Recombinant ATRX antibody (AA 2200-2450)

Catalog No. ABIN7872352

The Rabbit Monoclonal anti-ATRX antibody (Clone ATRX-7188R) (ABIN7872352) specifically detects ATRX in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant ATRX antibody (AA 2200-2450) (ABIN7872352)

Target: ATRX (helicase 2, X-linked (ATRX))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ATRX antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: ATRX-7188R

Product Details anti-ATRX Antibody

Binding Specificity: AA 2200-2450

Purpose: ATRX Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 2200-2450 from the human protein was used as the immunogen for the ATRX antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the ATRX antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the ATRX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Alternative Name: ATRX

Background: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 thalassemia or ATRX syndrome

UniProt: P46100