L1CAM antibody (AA 223-1218)

Catalog No. ABIN7872373

The Rabbit Polyclonal anti-L1CAM antibody (ABIN7872373) specifically detects L1CAM in WB, ELISA and FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for L1CAM antibody (AA 223-1218) (ABIN7872373)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L1CAM antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-L1CAM Antibody

Binding Specificity: AA 223-1218

Purpose: CD171 Antibody / L1CAM / NCAM-L1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids E223-Q1218) was used as the immunogen for the CD171 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CD171 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CD171 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: CD171

Background: L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

UniProt: P32004

Pathways: Synaptic Membrane