ICOSLG antibody (AA 23-149)

Catalog No. ABIN7872483

The Mouse Monoclonal anti-ICOSLG antibody is suitable to detect ICOSLG in samples from Human. It has been validated for ELISA and IHC (p).

Quick Overview for ICOSLG antibody (AA 23-149) (ABIN7872483)

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICOSLG antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ICOSL-3260

Product Details anti-ICOSLG Antibody

Binding Specificity: AA 23-149

Purpose: ICOS Ligand Antibody / ICOS-L / B7RP-1

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 23-149) was used as the immunogen for the ICOS Ligand antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the ICOS Ligand antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the ICOS Ligand antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ICOSLG

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Alternative Name: ICOS Ligand

Background: This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.

UniProt: O75144

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation