KLHL12 antibody (AA 23-327)

Catalog No. ABIN7872525

The Rabbit Polyclonal anti-KLHL12 antibody is suitable to detect KLHL12 in samples from Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for KLHL12 antibody (AA 23-327) (ABIN7872525)

Target: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHL12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KLHL12 Antibody

Binding Specificity: AA 23-327

Purpose: Zebrafish Klhl12 Antibody / Kelch-like protein 12

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Klhl12 recombinant protein (amino acids R23-V327) was used as the immunogen for the Zebrafish Klhl12 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Klhl12 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Klhl12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for KLHL12

Target: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Alternative Name: Klhl12

Background: Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene. This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants.

UniProt: Q5U374