FIP1L1 antibody (AA 23-558)

Catalog No. ABIN7872545

This Rabbit Polyclonal antibody specifically detects FIP1L1 in WB, IF, ELISA, IHC (p) and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FIP1L1 antibody (AA 23-558) (ABIN7872545)

Target: FIP1L1 (FIP1 Like 1 (FIP1L1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FIP1L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-FIP1L1 Antibody

Binding Specificity: AA 23-558

Purpose: FIP1L1 Antibody / Pre-mRNA 3'-end-processing factor FIP1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids E23-E558) was used as the immunogen for the FIP1L1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FIP1L1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the FIP1L1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for FIP1L1

Target: FIP1L1 (FIP1 Like 1 (FIP1L1))

Alternative Name: FIP1L1

Background: Factor interacting with PAPOLA and CPSF1 (i.e, FIP1L1, also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: Q6UN15