MEG3 antibody (AA 23-561)

Catalog No. ABIN7872547

The Rabbit Polyclonal anti-MEG3 antibody (ABIN7872547) specifically detects MEG3 in WB, ELISA, IHC (p) and FACS. The antibody is reactive with Human samples.

Quick Overview for MEG3 antibody (AA 23-561) (ABIN7872547)

Target: MEG3 (FAM129B) (Family with Sequence Similarity 129, Member B (FAM129B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEG3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-MEG3 Antibody

Binding Specificity: AA 23-561

Purpose: FAM129B Antibody / MINERVA / NIBAN2

Purification: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids K23-K561) was used as the immunogen for the FAM129B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FAM129B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the FAM129B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MEG3

Target: MEG3 (FAM129B) (Family with Sequence Similarity 129, Member B (FAM129B))

Alternative Name: FAM129B

Background: FAM129B/Niban-like protein 1 (family with sequence similarity 129, member B) belongs to a poorly characterized family of Niban proteins that also includes FAM129A/Niban and FAM129C/Niban-like protein 2. FAM129A/Niban is implicated in the ER stress response and is upregulated at the protein level in thyroid carcinoma. FAM129C/Niban-like protein 2 is preferentially expressed in B-cells and is one of five biomarkers upregulated in whole blood from patients with colorectal carcinoma. FAM129B is broadly expressed and has been shown to be a downstream target of B-Raf in melanoma cells. Though FAM129B does not appear to regulate cell growth and division, phosphorylation of FAM129B by B-Raf is essential for the invasive potential of melanoma and non-melanoma cell lines. Deletion of FAM129B in melanoma cells significantly impairs B-Raf/MEK/Erk-dependent invasion into the extracellular matrix.

UniProt: Q96TA1