AANAT antibody (AA 24-205)

Catalog No. ABIN7872672

The Rabbit Polyclonal anti-AANAT antibody is suitable to detect AANAT in samples from Mouse. It has been validated for ELISA and WB.

Quick Overview for AANAT antibody (AA 24-205) (ABIN7872672)

Target: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AANAT antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-AANAT Antibody

Binding Specificity: AA 24-205

Purpose: Aanat Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant mouse Aanat protein (amino acids C24-C205) was used as the immunogen for the Aanat antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Aanat antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Aanat antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for AANAT

Target: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Alternative Name: Aanat

Background: Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb AANAT gene containing four exons, located on chromosome 17q25. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants.

UniProt: O88816

Pathways: Photoperiodism