SYT17 antibody (AA 24-304)

Catalog No. ABIN7872681

The Rabbit Polyclonal anti-SYT17 antibody is suitable to detect SYT17 in samples from Human. It has been validated for WB, ELISA, IF and ICC.

Quick Overview for SYT17 antibody (AA 24-304) (ABIN7872681)

Target: SYT17 (Synaptotagmin XVII (SYT17))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYT17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-SYT17 Antibody

Binding Specificity: AA 24-304

Purpose: SYT17 Antibody / Synaptotagmin 17

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SYT17 recombinant protein (Position: R24-K304) was used as the immunogen for the SYT17 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SYT17 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SYT17 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SYT17

Target: SYT17 (Synaptotagmin XVII (SYT17))

Alternative Name: SYT17

Background: SYT17 antibody detects Synaptotagmin-17 (also known as Synaptotagmin XVII), a member of the synaptotagmin family of membrane-trafficking proteins that regulate vesicle docking and fusion. Encoded by the SYT17 gene on chromosome 16q21, this isoform differs from classical synaptotagmins by lacking the N-terminal transmembrane region, suggesting a soluble or peripheral membrane association. SYT17 contains tandem C2 domains that mediate calcium-dependent phospholipid binding and interactions with SNARE complex proteins. Through these domains, Synaptotagmin-17 contributes to intracellular trafficking, membrane remodeling, and possibly exocytosis in non-neuronal tissues.

Unlike canonical synaptotagmins that function in neurotransmitter release, SYT17 is primarily expressed in non-synaptic regions of the brain, kidney, and liver, where it regulates membrane trafficking between the endoplasmic reticulum and Golgi apparatus. It may modulate calcium-sensitive steps in vesicle fusion and contribute to secretory pathway organization. In neurons, SYT17 expression has been linked to dendritic cargo transport and neurite extension, implicating it in intracellular trafficking rather than synaptic vesicle exocytosis. Loss or mutation of SYT17 alters intracellular transport dynamics, potentially affecting neural development and metabolic processes.

The SYT17 antibody is used in neuroscience and cell biology to detect Synaptotagmin-17 expression and subcellular localization. Western blot analysis typically identifies a ~50 kilodalton band, while immunofluorescence reveals punctate cytoplasmic staining consistent with endomembrane localization. In neuronal cultures, SYT17 co-localizes with markers of the Golgi network and early endosomes, indicating its role in vesicular transport. The antibody aids in studying membrane trafficking, calcium signaling, and synaptotagmin family diversification.

Functionally, SYT17 binds phospholipids in a calcium-dependent manner and may participate in regulating the SNARE machinery under specific conditions. It also interacts with proteins involved in vesicle tethering and sorting. Dysregulated SYT17 expression has been reported in certain neurodegenerative disorders and cancers, though its exact pathogenic roles remain under investigation. NSJ Bioreagents provides this SYT17 antibody validated for its applications, ensuring high specificity for basic and translational research on intracellular transport and signaling.

UniProt: Q9BSW7