CXCL12 antibody (AA 24-99)

Catalog No. ABIN7872728

This Rabbit Polyclonal antibody specifically detects CXCL12 in IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for CXCL12 antibody (AA 24-99) (ABIN7872728)

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCL12 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CXCL12 Antibody

Binding Specificity: AA 24-99

Purpose: Zebrafish Cxcl12 Antibody / Cxcl12a / Cxcl12b

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Cxcl12 recombinant protein (amino acids K24-V99) was used as the immunogen for the Zebrafish Cxcl12 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Cxcl12 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Cxcl12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CXCL12

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Alternative Name: Cxcl12

Background: Cxcl12, also known as stromal cell-derived factor 1, is a chemokine that plays a crucial role in the regulation of cell migration, particularly during embryonic development and immune cell trafficking. In zebrafish, Cxcl12 is essential for the proper guidance of various cell types, including primordial germ cells, neural crest cells, and hematopoietic stem cells.

Cxcl12 signals through its receptor Cxcr4, and this signaling axis is conserved across vertebrates. In zebrafish embryos, Cxcl12 is expressed in defined tissue regions and acts as a chemoattractant, guiding migrating cells to their correct destinations. It is also involved in vascular development, organ positioning, and fin regeneration.

Because of its conserved function and well-characterized roles in developmental and immune processes, zebrafish Cxcl12 is widely used as a model for studying chemokine signaling, stem cell migration, tumor metastasis, and inflammatory responses. It is also a valuable tool in regenerative biology and drug discovery targeting chemokine pathways.

UniProt: Q8AV10

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling