Recombinant LI Cadherin antibody (AA 242-418)

Catalog No. ABIN7872764

This Rabbit Monoclonal antibody specifically detects LI Cadherin in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant LI Cadherin antibody (AA 242-418) (ABIN7872764)

Target: LI Cadherin

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This LI Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CDH17-8513R

Product Details anti-LI Cadherin Antibody

Binding Specificity: AA 242-418

Purpose: Cadherin 17 Antibody / CDH17 (azide and preservative free)

Purification: Protein A affinity

Immunogen: A recombinant partial protein sequence (within amino acids 242-418) from the human protein was used as the immunogen for the Cadherin 17 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Cadherin 17 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Cadherin 17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for LI Cadherin

Target: LI Cadherin

Alternative Name: Cadherin 17

Background: It recognizes a protein of 120 kDa, which is identified as Cadherin 17 (also known as LI Cadherin). The cadherins are a family of Calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.

UniProt: Q12864