Recombinant LI Cadherin antibody (AA 242-418)

Catalog No. ABIN7872767

This Mouse Monoclonal antibody specifically detects LI Cadherin in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant LI Cadherin antibody (AA 242-418) (ABIN7872767)

Target: LI Cadherin

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LI Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RCDH17-8514

Product Details anti-LI Cadherin Antibody

Binding Specificity: AA 242-418

Purpose: LI Cadherin Antibody / Cadherin 17

Purification: Protein A affinity

Immunogen: A recombinant partial protein sequence (within amino acids 242-418) from the human protein was used as the immunogen for the LI Cadherin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the LI Cadherin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the LI Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for LI Cadherin

Target: LI Cadherin

Background: It recognizes a protein of 120 kDa, which is identified as Cadherin 17 (also known as LI Cadherin). The cadherins are a family of Calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.

UniProt: Q12864