STRN3 antibody (AA 243-690)

Catalog No. ABIN7872774

The Rabbit Polyclonal anti-STRN3 antibody is suitable to detect STRN3 in samples from Mouse, Human and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for STRN3 antibody (AA 243-690) (ABIN7872774)

Target: STRN3 (Striatin, Calmodulin Binding Protein 3 (STRN3))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRN3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-STRN3 Antibody

Binding Specificity: AA 243-690

Purpose: STRN3 Antibody / Striatin 3

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human STRN3 recombinant protein (Position: D243-H690) was used as the immunogen for the STRN3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STRN3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STRN3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STRN3

Target: STRN3 (Striatin, Calmodulin Binding Protein 3 (STRN3))

Alternative Name: STRN3

Background: STRN3 antibody detects Striatin-3, a calmodulin-binding scaffold protein that forms part of the striatin-interacting phosphatase and kinase (STRIPAK) complex. The UniProt recommended name is Striatin-3 (STRN3). This adaptor protein coordinates protein phosphatase 2A (PP2A) signaling and regulates cytoskeletal organization, cell migration, and signal transduction.

Functionally, STRN3 antibody identifies an 837-amino-acid protein that serves as a platform for assembling PP2A catalytic and regulatory subunits along with kinases such as MST3 and GCKIII family members. STRN3 modulates dephosphorylation of signaling proteins involved in cell adhesion, polarity, and morphogenesis. Its calmodulin-binding domain enables calcium-dependent regulation of complex formation.

The STRN3 gene is located on chromosome 14q12 and is expressed in various tissues, with particularly high levels in brain and heart. STRN3 participates in diverse signaling pathways, including the Hippo pathway, where it regulates MST1/2 kinase activity and contributes to growth control and organ size regulation. Its scaffold function allows spatial coordination between kinases and phosphatases within signaling microdomains.

Pathologically, aberrant STRN3 activity has been linked to cancer progression, cardiac hypertrophy, and neuronal dysfunction. Dysregulated STRIPAK signaling disrupts phosphorylation balance and cytoskeletal remodeling. STRN3 expression changes have been observed in glioblastoma and colon carcinoma, underscoring its importance in cell growth and motility.

STRN3 antibody is suitable for western blotting, immunofluorescence, and co-immunoprecipitation to identify PP2A-associated signaling complexes. NSJ Bioreagents provides validated STRN3 antibody reagents for research in kinase-phosphatase networks, cytoskeletal regulation, and signal transduction.

Structurally, Striatin-3 includes an N-terminal caveolin-binding motif, coiled-coil regions for oligomerization, a calmodulin-binding site, and WD-repeat domains for protein interactions. This antibody aids studies into STRN3's role as a scaffold coordinating phosphatase and kinase communication across multiple pathways.

UniProt: Q13033

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling