GCLM antibody (AA 246-274)

Catalog No. ABIN7872786

The Rabbit Polyclonal anti-GCLM antibody is suitable to detect GCLM in samples from Human and Mouse. It has been validated for WB, IF, FACS and IHC (p).

Quick Overview for GCLM antibody (AA 246-274) (ABIN7872786)

Target: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCLM antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GCLM Antibody

Binding Specificity: AA 246-274

Purpose: GCLM Antibody / Glutamate-Cysteine Ligase Regulatory Subunit

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 246-274 from the human protein were used as the immunogen for the GCLM antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the GCLM antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GCLM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GCLM

Target: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Alternative Name: GCLM

Background: GCLM known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

UniProt: P48507