MEK1/2 antibody (pSer218, pSer222)

Catalog No. ABIN743813

Product Details anti-MEK1/2 Antibody

Target: MEK1/2 (MAP2K1/2) (Mitogen-Activated Protein Kinase Kinase 1/2 (MAP2K1/2))

Binding Specificity: pSer218, pSer222

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEK1/2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: These phosphorylation sites are homologous to Ser222 + Ser226 in MEK2 and are the same across the listed species.

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human MEK1 around the phosphorylation site of Ser218/222

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MEK1/2

Target: MEK1/2 (MAP2K1/2) (Mitogen-Activated Protein Kinase Kinase 1/2 (MAP2K1/2))

Alternative Name: MEK1/2 + (MAP2K1/2 Products)

Background:

Synonyms: MAP2K1phospho S218/S222, Dual specicity mitogen activated protein kinase kinase 1, ERK activator kinase 1, MAP kinase kinase 1, MAP kinase/Erk kinase 1, MAP/Erk kinase 1, Map2K1, MAPK/ERK kinase 1, MAPKK 1, MAPKK1, MEK 1, MEKK1, Mitogen activated protein kinase kinase 1, MKK 1, MKK1, PRKMK 1, PRKMK1,Protein kinase mitogen activated kinase 1 MAP kinase kinase 1, Protein kinase mitogen activated kinase 1, Protein kinase mitogen activated, kinase 1.

Background: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Gene ID: 56045605