GnRH2 antibody (AA 25-86)

Catalog No. ABIN7872895

The Rabbit Polyclonal anti-GnRH2 antibody (ABIN7872895) specifically detects GnRH2 in IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for GnRH2 antibody (AA 25-86) (ABIN7872895)

Target: GnRH2 (Gonadotropin-Releasing Hormone 2 (GnRH2))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GnRH2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GnRH2 Antibody

Binding Specificity: AA 25-86

Purpose: Zebrafish Gnrh2 Antibody / Gonadotropin-releasing hormone 2 / Progonadoliberin

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Gnrh2 recombinant protein (amino acids Q25-K86) was used as the immunogen for the Zebrafish Gnrh2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Gnrh2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Gnrh2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GnRH2

Target: GnRH2 (Gonadotropin-Releasing Hormone 2 (GnRH2))

Alternative Name: Gnrh2

Background: Gonadotropin-releasing hormone 2 (Gnrh2) is a neuropeptide encoded by the gnrh2 gene in zebrafish (Danio rerio) and belongs to the conserved family of GnRH peptides that play essential roles in the regulation of reproductive physiology. Gnrh2 is primarily expressed in the midbrain tegmentum and is involved in modulating reproductive behavior, neuroendocrine signaling, and possibly feeding and locomotor activity.

Unlike Gnrh1, which is the main hypophysiotropic form regulating pituitary gonadotropin release, Gnrh2 is considered a non-hypophysiotropic GnRH variant and is thought to function in neuromodulation and reproductive behavior across vertebrates. In zebrafish, Gnrh2-expressing neurons have been implicated in the integration of sensory and hormonal signals, contributing to the fine-tuning of reproductive timing and behavior in response to environmental cues.

Due to its evolutionary conservation and tissue-specific expression, zebrafish Gnrh2 is a valuable model for studying neuroendocrine regulation, sexual behavior, and the functional diversification of GnRH isoforms.

UniProt: Q5Y835

Pathways: Hormone Activity