CDH6 antibody (AA 250-450)

Catalog No. ABIN7872908

This Mouse Monoclonal antibody specifically detects CDH6 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for CDH6 antibody (AA 250-450) (ABIN7872908)

Target: CDH6 (K-Cadherin (CDH6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDH6 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CDH6-3191

Product Details anti-CDH6 Antibody

Binding Specificity: AA 250-450

Purpose: Cadherin 6 Antibody / CDH6 / K-Cadherin

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 250-450) from the human protein was used as the immunogen for the Cadherin 6 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Cadherin 6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Cadherin 6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDH6

Target: CDH6 (K-Cadherin (CDH6))

Alternative Name: Cadherin 6

Background: This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. This protein may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.

UniProt: P55285

Pathways: Cell-Cell Junction Organization