Cyclin T1 antibody (AA 253-281)

Catalog No. ABIN7872934

The Rabbit Polyclonal anti-Cyclin T1 antibody (ABIN7872934) specifically detects Cyclin T1 in WB and FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for Cyclin T1 antibody (AA 253-281) (ABIN7872934)

Target: Cyclin T1 (CCNT1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin T1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-Cyclin T1 Antibody

Binding Specificity: AA 253-281

Purpose: CCNT1 Antibody / Cyclin T1

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 253-281 from the human protein was used as the immunogen for the CCNT1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the CCNT1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CCNT1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Cyclin T1

Target: Cyclin T1 (CCNT1)

Alternative Name: CCNT1

Background: CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

UniProt: O60563