Rhotekin antibody (AA 255-554)

Catalog No. ABIN7872939

The Rabbit Polyclonal anti-Rhotekin antibody is suitable to detect Rhotekin in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for Rhotekin antibody (AA 255-554) (ABIN7872939)

Target: Rhotekin (RTKN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Rhotekin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Rhotekin Antibody

Binding Specificity: AA 255-554

Purpose: Rhotekin Antibody / RTKN

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids R255-Q554) was used as the immunogen for the Rhotekin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Rhotekin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Rhotekin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Rhotekin

Target: Rhotekin (RTKN)

Alternative Name: Rhotekin

Background: Rhotekin is a protein that in humans is encoded by the RTKN gene. This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q9BST9