DNMT3B antibody (AA 258-472)

Catalog No. ABIN7872975

The Rabbit Polyclonal anti-DNMT3B antibody is suitable to detect DNMT3B in samples from Human, Mouse, Rat and Monkey. It has been validated for WB, ELISA and FACS.

Quick Overview for DNMT3B antibody (AA 258-472) (ABIN7872975)

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNMT3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-DNMT3B Antibody

Binding Specificity: AA 258-472

Purpose: DNMT3b Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M258-D472) was used as the immunogen for the DNMT3b antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DNMT3b antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the DNMT3b antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for DNMT3B

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Alternative Name: DNMT3b

Background: DNA (cytosine-5-)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

UniProt: Q9UBC3